IMCAS World Congress 2025
Program

Objectives: Open-label split face clinical trial assessing the safety and efficacy of Adipose Stem Cell Derived Exosomes vs PRP post RF microneedling in the cosmetic improvement of facial photoaged skin

Introduction: Exosomes and P.RP are finding their roles in aesthetic medicine

Materials / method: 15 subjects FP I-IV between ages 44-68 years old. Subjects received 3 RF microneedling treatments to the full face spaced at 4-week intervals.
Post treatment, PRP applied to right side and exosomes to the left side of the face.
Followed for 6 months post final treatment. 4 biopsies were taken from the right & left infra-auricular area at: Baseline; After final treatment (Tx 3); 3-month follow-up and: 6-month follow-up.
Investigator and subject assessments were undertaken regarding overall skin appearance, wrinkling, dyschromia, erythema, and textural quality.

Results: Exosomes and PRP indicated comparable histological results. 
Exosomes showed slightly better results than PRP in Investigator visual assessments. 

Conclusion: Exosomes are less invasive as they do not require blood draw. 
Can result in equal or improved efficacy than PRP. 

PRP is harvested from the patient's own blood, reflecting their age, whereas exosomes are harvested from healthy donors aged 18 to 25 years, potentially offering more robust regenerative properties.

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): Benev

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability