Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: To analyse the immunological foundations underlying biostimulators' mechanisms of action and their consequent relevance to aesthetic medicine in clinical settings.

Introduction: A key focus of regenerative aesthetics is the ability to manipulate wound healing processes towards regeneration by creating new tissue with the normal structure and function of the original tissue. Injectors achieve this through biostimulators that function through regenerative wound healing mechanisms. These mechanisms require the involvement of the extracellular matrix (ECM), which plays a crucial part by influencing cell behaviours.

Materials / method: An comprehensive review of the literature was undertaken to investigate the various immune responses elicited by frequently utilised biostimulators, such as poly-L-lactic acid (PLLA), polycaprolactone (PCL), and calcium hydroxylapatite (CaHA). The study placed particular emphasis on examining these substances' physicochemical characteristics and their effects in clinical settings

Results: . Calcium hydroxyapatite (CaHA) and poly-L-lactic acid (PLLA) have been found to elicit different responses by macrophages, leading to different immunological wound healing pathways. CaHA initiates a regenerative healing response, stimulating production of all the ECM elements: collagen, elastin, and ground matrix. PLLA polymer induces a different macrophage response initiating a predominantly replacement pathway with collagen. Cytokine expression profiles reflected the different macrophage responses to CaHA and PLLA in an in vitro study. It is not only the particles’ physicochemical attribute

Conclusion: The physicochemical properties, size and shape of biostimulant particles will influence whether the response pathway is going to be driven more towards regeneration or towards replacement. Other factors, such as injection technique and contamination, can influence the immunological response. These findings underscore the need for tailored treatment plans based on each biostimulator’s unique properties.

Disclosures

Did you receive any funding to support your research for this TOPIC?
Yes
Please specify entities (individual, company, society): Merz Aesthetics supported a clinical writer

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: To explore the efficacy, mechanisms, and clinical applications of hybrid fillers as an advanced solution for skin rejuvenation and volumization. This abstract evaluates the dual-action benefits of hybrid fillers, emphasizing their role in both immediate aesthetic enhancement and long-term tissue stimulation.

Introduction: Hybrid fillers have emerged as a transformative innovation in the field of aesthetic medicine, addressing the increasing demand for products that deliver both instant and sustained results. These fillers uniquely combine hyaluronic acid (HA) for immediate volumization and hydration with biostimulatory agents, such as calcium hydroxyapatite or poly-L-lactic acid, to promote collagen and elastin production. This dual mechanism not only restores facial contours but also enhances skin quality, making hybrid fillers a preferred choice for comprehensive rejuvenation.

Results: By combining the benefits of traditional fillers with biostimulatory properties, hybrid fillers not only provide immediate volume restoration but also enhance collagen production for long-term skin revitalization.
The dual-action mechanism allows for a synergistic effect, promoting natural and sustained improvements in skin quality and texture.

Conclusion: Hybrid fillers represent a paradigm shift in skin rejuvenation, offering both immediate improvements and progressive enhancements to skin structure and texture. Their versatility and biostimulatory properties make them an invaluable tool for aesthetic practitioners seeking to address diverse patient concerns, from volume loss to fine lines and skin laxity. As advancements in formulation continue, hybrid fillers are poised to redefine the standards of non-surgical rejuvenation, providing natural, long-lasting, and safe outcomes.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Objectives: 1. Review the changes associated with photoaging of the face, neck, chest
2. Review the science behind a novel formulation of trichloroacetic acid and hydrogen peroxide for topical biostimulation of neocollagenesis
3. Understand how topical bio stimulation can be combined with energy based treatments, such as radio frequency, high intensity focused ultrasound, fractional resurfacing, and lasers for skin rejuvenation.

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability

Disclosures

Did you receive any funding to support your research for this TOPIC?
No

Were you provided with any honoraria, payment or other compensation for your work on this study?
No

Do you have any financial relationship with any entity which may closely compete with the medications, materials or instruments covered by your study?
No

Do you own or have you applied for any patents in conjunction with the instruments, medications or materials discussed in your study?
No

This work was not supported by any direct or non direct funding. It is under the author's own responsability