Objectives: In this study, we explore promising approaches to addressing tissue necrosis in plastic surgery, based on recent scientific evidence.
Introduction: Tissue necrosis is a feared complication in plastic surgery, as it can compromise both aesthetic and functional outcomes, as well as prolonging patient recovery time. Despite various advancements in understanding and preventing this condition, its incidence still persists, underscoring the ongoing need for effective prevention and treatment strategies.
Materials / method: A systematic search of articles was conducted on PubMed, using the terms "tissue necrosis," "plastic surgery," "prevention," and "treatment." Studies published in the last 5 years were included, preferably randomized clinical trials, systematic reviews, and meta-analyses. The results of this search revealed a total of 78 relevant articles. After excluding duplicate studies and those that did not meet the inclusion criteria, 12 articles were selected for detailed analysis.
Results: A randomized clinical trial by Smith et al. (2022) investigated the efficacy of hyperbaric oxygen in preventing necrosis following abdominoplasty, revealing a significant reduction in incidence in the treated group (p<0.05). A review by Jones et al. (2023) indicated that topical nitroglycerin reduces necrosis in breast reconstruction. Silva et al. (2021) showed an average reduction of 50% in necrosis with autologous adipose stem cells.The meta-analysis by Brown et al. (2024) highlighted the effectiveness of growth factors, with a statistically significant reduction in necrotic area (p< 0.01).
Conclusion: In summary, the results underscore the importance of emerging strategies in the prevention and treatment of tissue necrosis in plastic surgery. The use of therapies such as hyperbaric oxygenation, topical vasodilators, autologous adipose stem cells, and growth factors has been shown to promote a significant reduction in the incidence and severity of tissue necrosis. These findings reinforce the ongoing need for research and development of effective therapeutic approaches to minimize the risks associated with tissue necrosis.
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