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IMCAS Asia 2024
Programa

DESTAQUE NA 096

Contributed Talks - Regenerative medicine

Sala: Room 2 - Level 2
Data: domingo 23 junho 2024 de 16:00 às 17:00
Formato: PALESTRAS CONTRIBUÍDAS > sessão composta por resumos submetidos que foram cuidadosamente revisados e selecionados pelo Conselho Científico

Moderadores

Dr Hugues CARTIER

Dermatologista

França

Dr Diane Irvine DUNCAN

Cirurgião Plástico

Estados Unidos da América

Apresentações desta sessão

Horas	Palestrantes	Título da apresentação	Resumo	Número
16:00	Dr Fui Ping LIM	Cord Lining Mesenchymal Stem Cells (CL-MSCs) Enhance the Structure, Thickness and Alignment of Collagen in Tissues Regeneration	Visualizar	134623
16:12	Dr Ali AL AMRI	Exosome indications in dermatology: what’s new?	Visualizar	134622
16:24	Dr Piyush BHADABHAI BORKHATARIYA	Injectable PRF for anti ageing aesthetic treatment - an Asian perspective	Visualizar	134624
16:36		Discussion and Q&A		134625

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Ir para a próxima sala (Room 3 - Level 2)

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Exossomos

Platelet-rich plasma (PRP)

Stem cells

Anti-aging

Queloides

Dr Fui Ping LIM

PhD - Investigação

Singapura

Outro(s) autor(es) : Assoc Prof Phan Toan Thang, Assoc Prof Alvin Chua

Cord Lining Mesenchymal Stem Cells (CL-MSCs) Enhance the Structure, Thickness and Alignment of Collagen in Tissues Regeneration

Objectives: To investigate whether the application of Cord Lining-Mesenchymal Stem Cells (CL-MSCs) improve collagen architecture, using Transmission Electron Microscopy (TEM) microscopic study to examine the collagen fiber diameter and orientation.

Introduction: Collagen, the primary protein in our skin, is essential for maintaining a smooth and firm appearance. However, collagen production diminishes as we age, resulting in visible aging signs like wrinkles, fine lines, and decreased skin elasticity. Stem cell treatments offer a groundbreaking solution to this problem. By targeting the skin at its cellular core, these treatments stimulate collagen regeneration, empowering the skin to regain its youthful structure from the inside out.

Materials / method: The study utilised 6 pigs, with 6 wounds created onto each pigs. The 6 pigs were randomly divided into three groups, with CL-MSCs delivered through (i) topical route (ii) intraperitoneal route and (iii) control group. Histopathological analysis and evaluation of collagen fibers were evaluated through Masson’s Trichrome stained photographs. The photograph were viewed and analyzed using Philips IMS v2.4 to study the collagen architectural of the tissues biopsied. Transmission Electron Microscopy was used to evaluate collagen ultrastructure, based on fiber orientation and fiber diameter

Results: The treated tissues showed accelerated collagen deposition in the granulation tissues of the CL-MSCs treated tissues. The median percentage of collagen deposition was highest for IP treated tissues. The control tissues consistently contain the lowest percentage of collagen deposition, either barely resurfaced or not resurfaced at all and with collagen ﬁbers that were loosely arranged with no dominant direction. The collagen fibers in the treated tissues were thicker and stronger in appearance, while the fibers of the control tissues were delicate and frail.

Conclusion: This study shows that the collagen fibers in tissues from CL-MSCs treated pigs were more mature in appearance. The fibers in CL-MSCs treated tissues were bundled into a neat pattern and have significantly thicker fibers as compared to control tissues. Collagen fibers from the control tissues were frail and weak in appearance, disorganized and scattered throughout all examined time points, and evidently the narrowest fibers.

Divulgação de informações

Você recebeu algum patrocínio para sua pesquisa neste tema?
Sim
Por favor indique a entidade (pessoa ou empresa): Cell Research Corp

Você recebeu algum tipo de honorário, pagamento ou outra forma de compensação por seu trabalho neste estudo?
Não

Você possui relação financeira com alguma entidade que possa competir com os medicamentos, materiais ou instrumentos abordados no seu estudo?
Não

Você detém ou pediu a registro de patente para algum dos instrumentos, medicamentos ou materiais abordados no seu estudo?
Não

Este trabalho não recebeu nenhum patrocínio direto ou indireto. O mesmo está sob a própria responsabilidade do seu autor.

Dr Ali AL AMRI

Dermatologista

Arábia Saudita

Outro(s) autor(es) :

Exosome indications in dermatology: what’s new?

Objectives: This study aims to provide a comprehensive overview of exosomes' emerging role in dermatology and aesthetic medicine, highlighting their potential therapeutic applications.

Introduction: Exosomes are nanoscale vesicles derived from cells, recognized in regenerative medicine for their capability to transport diverse biomolecules such as proteins, nucleic acids, and lipids. These vesicles are key mediators of intercellular. communication, impacting critical cellular processes including proliferation, differentiation, migration, and cell death.

Materials / method: Leveraging our extensive experience in exosome-based treatments for over 2000 patients, this study synthesizes recent research to outline the mechanisms and potential applications of exosomes in various dermatological and aesthetic procedures.

Results: Exosomes show promise as therapeutic agents in a broad spectrum of dermatological and aesthetic interventions, including wound healing, scar management, skin aging reversal, facial rejuvenation, pigmentation issues, psoriasis, atopic
dermatitis, vitiligo, lupus, sclerosis, and hair growth. Their multifaceted
mechanisms offer versatile solutions for numerous dermatological conditions and aesthetic improvements.

Conclusion: The growing research on exosomes underscores their transformative potential in dermatology and aesthetic medicine. Harnessing exosomes' regenerative properties could revolutionize treatment approaches for various skin conditions and aesthetic. needs. Further research is encouraged to fully unlock their therapeutic
potential and innovate clinical applications.

Divulgação de informações

Você recebeu algum patrocínio para sua pesquisa neste tema?
Não

Você recebeu algum tipo de honorário, pagamento ou outra forma de compensação por seu trabalho neste estudo?
Não

Você possui relação financeira com alguma entidade que possa competir com os medicamentos, materiais ou instrumentos abordados no seu estudo?
Não

Você detém ou pediu a registro de patente para algum dos instrumentos, medicamentos ou materiais abordados no seu estudo?
Não

Este trabalho não recebeu nenhum patrocínio direto ou indireto. O mesmo está sob a própria responsabilidade do seu autor.

Dr Piyush BHADABHAI BORKHATARIYA

Dermatologista

Índia

Outro(s) autor(es) :

Injectable PRF for anti ageing aesthetic treatment - an Asian perspective

Objectives: How injectable PRF is prepared & injected for anti ageing benefits. How PRF is prepared, what should be ideal centrifugation speed, type of tube for blood collection, type of centrifuge machine, how to extract PRF and how to inject in face & peri orbital area. Why PRF is superior than PRP.

Introduction: In recent years,Injectable Platelet-Rich Fibrin (PRF) has emerged as a promising therapy in dermatology, particularly in the realm of anti ageing & skin rejuvenation . As dermatologists, our pursuit of safe and effective solutions to combat the signs of aging is perpetual, and PRF presents a compelling answer to this dilemma.

This abstract aims to provide an overview of the mechanism, efficacy, and clinical applications of PRF in anti ageing & skin rejuvenation benefits.

Materials / method: • We have given injectable PRF to all patients. Bilateral intradermal injections into the malar area (1 mL each), nasolabial folds (0.5 mL each), and upper lip skin above the vermilion border (1 mL) were performed using a 32 g × 4 mm needle
• Individual 0.1-mL injections spaced 5 mm apart were administered to cover the three regions
• In total, approximately 4 mL of i-PRF in four 1-mL syringes was administered.

A 3cc PRF solution was injected into the wrinkles around the eyes with a canola number 27 on both sides.
The injection was performed at the sub-dermis site and in one session.

Results: We have compared Platelet rich plasma (PRP) with Platelet rich Fibrin (PRF) for its anti ageing benefits. We found that injectable PRF is better than PRP in producing anti ageing & skin rejuvenation benefits.
Significant improvement in several skin characteristics was mirrored by significant improvement in patient satisfaction, thereby suggesting a benefit for the use of i-PRF for facial skin rejuvenation.
Following PRF injection, in addition to improving deep wrinkles, noticeable improvement was observed in fine and small wrinkles, periocular hyperpigmentation, and overall skin freshness.

Conclusion: PRF is superior than PRP for anti ageing benefits
Liquid- injectable PRF is suitable for Facial rejuvenation & anti ageing
Centrifugation should be start within 90 seconds of blood collection
10 ml of blood required for making 1 ml of i-PRF.
i-PRF should be injected within 15 to 20 mins of preparation
PRF contains higher concentrations of platelets, fibrin, and leukocytes compared to other platelet-rich concentrates.
PRF not only represents a rich source of growth factors but also provides a scaffold to support true tissue regeneration.

Divulgação de informações

Você recebeu algum patrocínio para sua pesquisa neste tema?
Não

Você recebeu algum tipo de honorário, pagamento ou outra forma de compensação por seu trabalho neste estudo?
Não

Você possui relação financeira com alguma entidade que possa competir com os medicamentos, materiais ou instrumentos abordados no seu estudo?
Não

Você detém ou pediu a registro de patente para algum dos instrumentos, medicamentos ou materiais abordados no seu estudo?
Não

Este trabalho não recebeu nenhum patrocínio direto ou indireto. O mesmo está sob a própria responsabilidade do seu autor.

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IMCAS Asia 2024 Programa

DESTAQUE NA 096

Contributed Talks - Regenerative medicine

Moderadores

Apresentações desta sessão

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IMCAS Asia 2024
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